Blue-chip binding

Blue-chip binding

Heparin is an anionic polysaccharide that has tremendous clinical importance as an anticoagulant. Several dyes have been developed that can detect heparin, and the latest example — named Mallard Blue — has now been shown to have excellent sensing properties under biologically relevant conditions. Heparin and heparan sulfate (HS) are complex linear polysaccharides that modulate a range of normal...

Heparin sensing: blue-chip binding.

Heparin is an anionic polysaccharide that has tremendous clinical importance as an anticoagulant. Several dyes have been developed that can detect heparin, and the latest example — named Mallard Blue — has now been shown to have excellent sensing properties under biologically relevant conditions. Heparin and heparan sulfate (HS) are complex linear polysaccharides that modulate a range of normal...

Overview of the Blue CHiP Computer

ChIP-Chip: algorithms for calling binding sites.

Genome-wide ChIP-chip assays of protein-DNA interactions yield large volumes of data requiring effective statistical analysis to obtain reliable results. Successful analysis methods need to be tailored to platform specific characteristics such as probe density, genome coverage, and the nature of the controls. We describe the use of the respective software packages MAT and MA2C for the analysis ...

DNA-protein binding force chip.

Force measurements provide new fundamental and complementary information on biomolecular interactions, particularly in the high and low affi nity regimes, which may hardly be obtained otherwise. [ 1 ] We introduce a label free parallel format assay to quantify the binding forces in protein–DNA complexes on a chip in crowded environments. It employs arrays of molecular force balances with fl uor...